Hemorrhage and saline resuscitation are associated with epigenetic and proteomic reprogramming in the rat lung
In this study, the Sillesen group investigates the alteration of the proteome in the context of hemorrhage and saline resuscitation in trauma patients. They used rat lungs as a model and pooled 10 rats in one combined TMT experiment subjected to high pH offline...Standardized workflows for large cohort plasma profiling
Together, Thermo Fisher Scientific and Evosep are on a joint mission to develop standardized and scalable plasma protein quantitative profiling workflows. Our recent developments have been featured in an application note by the Precision Medicine Science Centre led by Dr. Emily Chen.
High-throughput methods for phosphotyrosine signaling
The need for scalable methods for functional annotation of phosphotyrosine sites has led the Olsen group, Novo Nordisk Foundation Center for Protein Research in Copenhagen, to develop a new mass spectrometry-based workflow for high-throughput analyses. In a recent study, they implemented this new workflow used to describe how cancer mutations close to tyrosine phosphorylation sites in the EGF receptor rewire signaling pathways by switching protein interactors.
Evosep One enables robust deep proteome coverage using tandem mass tags while significantly reducing instrument time
Jonathan Krieger, PhD, Senior Applications Scientist at Bioinformatics Solutions presented “Evosep One Enables Robust Deep Proteome Coverage Using Tandem Mass Tags while Significantly Reducing Instrument Time” showcasing recent data from the SPARC Biocentre at the Hospital for Sick Children.
