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The Host Interactome of Spike Expands the Tropism of SARS-CoV-2

by Eva Bryderup

This publication from the Yates lab, investigates the host interactome determining whether a SARS-CoV-2 infection is productive. They find an “S2 only” dependent, alternative infection of additional cell types with SARS-CoV-2 may impact vaccination strategies and...

Crystal structure of bacterial cytotoxic necrotizing factor CNFY reveals molecular building blocks for intoxication

by Eva Bryderup

In this study, researchers from the Helmholtz Centre for Infection Research determined the crystal structure of full-length Yersinia pseudotuberculosis CNFY, bacterial single-chain exotoxins that modulate cytokinetic and inflammatory processes through activation of...

Fluvastatin mitigates SARS-CoV-2 infection in human lung cells

by Eva Bryderup

Clinical data of patients suffering from COVID-19 have indicated that statin therapy, used to treat high cholesterol, is associated with a better clinical outcome. A collaboration led by Gisa Gerold investigated the effect of statins on SARS-CoV-2 infection in human...

ABPP-HT – high-throughput activity-based profiling of deubiquitylating enzyme inhibitors in a cellular context

by Eva Bryderup

This publication from University of Oxford led by Adan Pinto-Fernandez, describes a new methodology named ABPP-HT (high-throughput-compatible activity-based protein profiling), implementing a semi-automated proteomic sample preparation workflow that increases the...

Seroconversion stages COVID19 into distinct pathophysiological states

by Eva Bryderup

In this study, researchers from University of Colorado led by Joaquin M. Espinosa, found highly variable seroconversion status among hospitalized Covid-19 patients. Their results support the existence of distinct pathophysiological states, with seroconversion status...
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  • EuPA 2025
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