ApplicationsGet inspired with research from our users around the world and explore some of the many published applications with Evosep One
GET INSPIRED WITH PUBLISHED APPPLICATIONS
FROM OUR USERS
Evosep One offers a wide range of applications – from understanding the Covid-19 disease to the identification of proteins with short gradients.
Dive into the inspiring research from our users around the world and explore the possibilities of clinical proteomics with Evosep One.
In our monthly webinar series you can also explore some of the many applications covered by the Evosep One and meet our users. Visit our webinar page to upcoming and past events.
Automated sample prep workflows have gained in popularity in proteomics laboratories. With an increased sample throughput on the Evosep One, it is possible to prioritize a high number of technical and biological replicates in a dataset providing excellent strength in the downstream bioinformatic analysis.
Clinical research and routine analysis
Clinical proteomics is a broad topic from discovery proteomics to clinical diagnostics for informing clinical decision making.
With the rapid development and maturing of technologies used of clinical applications in a routine setting we are convinced that we are just in the beginning of what will be possible in this field.
Learn more about how to get started and how users have already implmented the Evosep One into at clinical setting.
SINGLE CELL PROTEOMICS AS A ROBUST AND STANDARDIZED APPLICATION
Single cell proteomics is a field in rapid development, enabled by significant technological improvements over the last years and it presents a key contribution to answer fundamental biological questions about heterogeneity within complex systems.
Explore how our customers have used the ultra sensitive Evosep One Whisper methods to achieve these technological advantages for single-cell proteomics.
A powerful combination: DIA combined with short gradients
Data independent acquisition (DIA) strategies have appeared as a powerful alternative to classic data dependent acquisition (DDA) in shotgun proteomics.
DIA offers systematic measurement of all peptide ions regardless of their intensity by co-fragmenting all co-eluting peptides in broader precursor isolation windows. This provides a wider dynamic range of the proteomes analyzed, improved reproducibility for identification and enables better sensitivity and accuracy for quantification.
REPRODUCIBLE PLASMA PERFORMANCE
Proteomics analysis of human blood offers an attractive and challenging pipeline for discovery of biomarkers. Over the last few years the need for, large cohort, plasma analysis using proteomic techniques has become more and more prevalent for both discovery and targeted workflows.
High throughput MS-based proteomics is being coupled with Machine learning, in order to identify significant biomarkers. Targeted workflows are then used to detect and quantify previously identified biomarkers.
Explore how the Evosep One, with high reproducibility and robustness, is ideally suited for analysis of large sample cohorts of blood plasma.
Targeted workflows are efficiently used to detect specific peptide ions to verify and validate specific biological hypotheses.
Combined with recent years technological advancements, this has led to the expansion of targeted strategies, which offer high sensitivity, quantitative accuracy and reproducibility.
Understanding the COVID-19 disease using rapid assays with high sensitivity
The global emergence of novel coronavirus disease 2019 (COVID-19) has underlined the requirement for rapid assays with high sensitivity and specificity for detection of infection and further to understand the molecular functions complexity of the disease.
Explore how, our customers have used the Evosep One to develop an effective screening assay and comprehensive understanding of the disease.
Fast and sensitive HCP screening
The growing field of biopharmaceutical drug development and production, has increased the demand for efficient and reproducible workflows for the detection of trace amounts of host cell proteins (HCPs) to ensure drug safety and purity.
Explore how, the Evosep One technology can speed up your HCP analysis.
Proteins are the fundamental building blocks and control all biological systems in a cell.
The physical interaction between proteins define specific biological functions and signaling networks.
Explore how our customers have used Evosep One to scale the study of complex protein environments and understand cell biology.
FFPE Tissue Analysis
While large biobanks offer an invaluable resource for clinical and biomarker research, it has been challenging to integrate FFPE tissue samples with proteomics studies.
Sensitive and reproducible workflows are needed for clinical studies in general, but more important for sample types as FFPE, where the biggest issue is to reverse the crosslinks and efficiently extract proteins.
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Fast and reproducible phosphoproteomics using MagReSyn® Amine and Ti-IMAC HP magnetic beads and the Evosep One
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