Applications

Get inspired with research from our users around the world and explore some of the many published applications with Evosep One

GET INSPIRED WITH PUBLISHED APPPLICATIONS
FROM OUR USERS

Evosep One offers a wide range of applications – from understanding the Covid-19 disease to the identification of proteins with short gradients.

Dive into the inspiring research from our users around the world and explore the possibilities of clinical proteomics with Evosep One.

In our monthly webinar series you can also explore some of the many applications covered by the Evosep One and meet our users. Visit our webinar page to upcoming and past events. 

Understanding the COVID-19 disease using rapid assays with high sensitivity

The global emergence of novel coronavirus disease 2019 (COVID-19) has underlined the requirement for rapid assays with high sensitivity and specificity for detection of infection and further to understand the molecular functions complexity of the disease.

Explore how, our customers have used the Evosep One to develop an effective screening assay and comprehensive understanding of the disease.

A powerful combination: DIA combined with short gradients

Data independent acquisition (DIA) strategies have appeared as a powerful alternative to classic data dependent acquisition (DDA) in shotgun proteomics.

DIA offers systematic measurement of all peptide ions regardless of their intensity by co-fragmenting all co-eluting peptides in broader precursor isolation windows. This provides a wider dynamic range of the proteomes analyzed, improved reproducibility for identification and enables better sensitivity and accuracy for quantification.

Fast and sensitive HCP screening

The growing field of biopharmaceutical drug development and production, has increased the demand for efficient and reproducible workflows for the detection of trace amounts of host cell proteins (HCPs) to ensure drug safety and purity.

Explore how, the Evosep One technology can speed up your HCP analysis.

REPRODUCIBLE PLASMA PERFORMANCE

Proteomics analysis of human blood offers an attractive and challenging pipeline for discovery of biomarkers. Over the last few years the need for, large cohort, plasma analysis using proteomic techniques has become more and more prevalent for both discovery and targeted workflows.

High throughput MS-based proteomics is being coupled with Machine learning, in order to identify significant biomarkers. Targeted workflows are then used to detect and quantify previously identified biomarkers. 

Explore how the Evosep One, with high reproducibility and robustness, is ideally suited for analysis of large sample cohorts of blood plasma.

 

Protein-protein interactions

Proteins are the fundamental building blocks and control all biological systems in a cell.

The physical interaction between proteins define specific biological functions and signaling networks.

Explore how our customers have used Evosep One to scale the study of complex protein environments and understand cell biology.

 

Targeted Workflows

Targeted workflows are efficiently used to detect specific peptide ions to verify and validate specific biological hypotheses. 

Combined with recent years technological advancements, this has led to the expansion of targeted strategies, which offer high sensitivity, quantitative accuracy and reproducibility.

Drug Discovery

As proteins are the targets for most drugs, proteomics is important to study novel targets and understand disease mechanisms and toxicity.

Explore, how the Evosep One technology is a valuable tool for high-throughput and reliable drug discovery.

 

FFPE tissue analysis

While large biobanks offer an invaluable resource for clinical and biomarker research, it has been challenging to integrate FFPE tissue samples with proteomics studies.

Sensitive and reproducible workflows are needed for clinical studies in general, but more important for sample types as FFPE, where the biggest issue is to reverse the crosslinks and efficiently extract proteins.

Automation

Automated sample prep workflows have gained in popularity in proteomics laboratories. With an increased sample throughput on the Evosep One, it is possible to prioritize a high number of technical and biological replicates in a dataset providing excellent strength in the downstream bioinformatic analysis.

DOWNLOAD OUR MATERIAL

application note
THE PROTEOMICS DILEMMA – HIGH THROUGHPUT ANALYSIS VERSUS PROTEOME DEPTH
case study
Unleashing the true power of DIA/SWATH data acquisition with short gradients
application note
Fast and reproducible phosphoproteomics using MagReSyn® Amine and Ti-IMAC HP magnetic beads and the Evosep One
case study
PAVING THE WAY TO CLINICAL PROTEOMICS
application note
FAST CONFIRMATORY ANALYSIS OF RHUEPOS IN PLASMA FOR HORSERACING DOPING CONTROL

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