Single cell proteomics is a relatively young niche of proteomics compared to single cell genomics. In the recent years, significant progress has been made in sample handling and boosting the sample signal by multiplexing with mass spectrometers. timsTOF SCP is the first commercially introduced mass spectrometer dedicated for single cell proteomics. The modified front-end (orthogonal ion-guiding) of the instrument increase the ion transfer up to five times and keeps ultra-high robustness – the default attribute of the timsTOF platform. Here we demonstrate the performance of the instrument for low sample loads in the range of 250 pg to 1 ng in combination with robust low flow rate delivery from the Evosep system.