The Epidemiology of Diabetes Interventions and Complications (EDIC) study was an observational follow-up of the Diabetes Control and Complications Trial (DCCT) to examine the long-term effects of the original DCCT interventions on diabetic complications such as cardiovascular diseases (CVD). Current observational based prediction models are inadequate in prediction of CVD. Amadori products originating from early step of protein glycation are associated with long-term complications. The aim of this study is to investigate whether Amadori products are sensitive molecular biomarkers for early diagnosis of CVD in the type 1 diabetes (T1D) population. To do so, we used high throughput and robust boronate affinity enrichment-based proteomics to profile the glycated proteins from the plasma samples collected in the EDIC study.
WP 299 – High Throughput Plasma Glycated Proteome Profiling to Discover Cardiovascular Disease Biomarkers from the Epidemiology of Diabetes Interventions and Complications Study
by Eva Bryderup