Together, Thermo Fisher Scientific and Evosep are on a joint mission to develop standardized and scalable plasma protein quantitative profiling workflows. Our recent developments have been featured in an application note by the Precision Medicine Science Centre led by Dr. Emily Chen.

For a reliable conclusion, the proteomics workflow identifying these markers must be robust and scalable in order to run hundreds or thousands of samples. Therefore, the aim of the study was to develop a standardized, high throughput, and reproducible workflow for blood-based biomarker discovery using automated sample preparation.

Fig. 1: An illustration of the high throughput plasma workflow with the Evosep LC coupled to a Q Exactive HF-X mass spectrometer

The workflow used in the app note consisted of an automated sample preparation method and analysis of samples on an Evosep One LC system coupled to a Thermo Scientific™ Q Exactive™ HF-X mass spectrometer and can be extensible to other Orbitrap or quadrupole-orbitrap series system.

See the results and read the full app note

Want to know more about our joined mission?

The data presented in the Application note is just one of the steps we have taken with Thermo Fisher Scientific to establish standardized workflows for large cohort plasma profiling.

Watch or re-watch our joint webinar with Dr. Emily Chen and Dr. Nicolai Bache supporting precision medicine through proteomic profiling for biomarker discovery here.

Here you can also find the latest press release from ASMS 2019 elaborating on the Thermo Fisher Scientific and Evosep collaboration.