Evosep at HUPO 2024

Evosep at Hupo 2024

We are thrilled to once again participate at the annual Human Proteomics Conference, which will take place in Dresden, Germany. Please visit us at booth 18, where will be happy to introduce you to our technology and how we can contribute with fully automated and standardized workflows. You are also welcome to join our Evosep Breakfast Seminar and/or our User Appreciation Event, register and secure your seat now.

See our activities at this year’s HUPO 2024.

New Press release

(Oct 2024) Evosep Expanding Capabilities with New Headquarters to Support Rising Needs in Pharma and Biotech for Proteomics

HUPO, Dresden, Germany – October 21st, 2024 – Evosep, a global leader in proteomics solutions, is proud to announce its relocation to new headquarters in Odense.

Read press release

Evosep webinar

HUPO 2024 Highlights: Standardizing and scaling automated workflows for cutting edge proteomics

Get an overview of all the highlights of Evosep at HUPO 2024, including new research, talks and much more from the conference.

When: November 14th at 4:00 pm CET

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New data and research

Get an overview of our new data presented at HUPO 2024.

poster

Standardized, fully automated neat plasma and mag-net enrichment workflows enables by the evotip pure

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poster

Enabling scalable single-cell proteomics by utilizing the unique analytics properties of the Evotip Pure with the new Whisper Zoom methods

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Application Note

Evotip pure for end-to-end workflows: a cost-efficient, sustainable and scalable proteomics solution

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Case Study

Whisper Zoom combines ease-of-use and simplicity for routine, high sensitivity workflows

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Abstracts

This year you can explore a lot of new research featuring Evosep One at HUPO. Below you can find a complete list of all the submitted abstract.

Title
PI0216 – Analyzing the proteome, N-glycoproteome and phosphoproteome of dried blood: method optimization and application to phenotyping of human sepsis
PI0103 – Enabling scalable single-cell proteomics by utilizing the unique analytical properties of the Evotip Pure and Whisper Zoom methods
PIII1106 – Plasma immunopeptidomic landscape in patients with alpha-1 antitrypsin deficiency
PIII1093 – Immunopeptidomics for the identification of microbiota-derived antigens in colorectal cancer
PIII1088 – Benchmarking of high-throughput immunopeptidomics workflows
PIII1085 – An optimized mild acid elution (MAE) sample preparation workflow enabling MS-based immunopeptidome analysis from less than 1×10^6 cells
PIII1071 – Proteomic insights into MrgD receptor deficiency: motor hyperactive- and compusilve-like phenotype, and synaptic dysfunction in the nigrostriatal pathway
PIII1041 – Mass-spectrometry based proteomics reveals tissue specific metabolic pertubations in a mitochondrial disease mouse model
PIII1023 – Investigation of Parkinson’s disease heterogeneity and driving factors based on DIA proteomics analysis of patient PBMC’s
PIII0966 – Mass spectrometry-based proteomics to explore intratumoral heterogeneity in PAX3::FOXO1 fusion positive rhabdomyosarcoma
PIII0940 – High throughput affinity pull-down interactomics
PIII0864 – Phenotypic drug discovery screen in human iPSC-derived macrophages using novel MALDI-TOF MS workflows and in-depth diaPASEF proteomics
PIII0856 – Comprehensive characterisation of CDK4/6 inhibitor tilaciclib in acute myeloid Leukaemia using proteomics approaches
PII0721 – Cross-platform proteomic profiling of plasma extracellular vesicles to identify biomarkers of malignant pulmonary modules
PII0697 – Ultra-deep MS based plasma proteomics in a hand foot and mouth disease cohort
PII0688 – MultiOmics landscape of pathotypes in rheumatoid arthritis – enroute to digital health using AI clinical diagnostics by nanoproteomics and AI based imaging diagnostics
PII0687 – Single Cell Deep Visual Proteomics (scDVP) of human hepatocytes in alpha-1 antitrypsin deficiency
PII0670 – Plasma proteome profiling reveals immunological dynamics in a longitudinal yellow FeverVaccination cohort
PII0658 – Comparative proteomic analysis of human ventricular tissue of over 100 patients undergoing heart transplantation
PII0646 – ZenoSWATH proteomics and clustering analysis reveal different modulation patterns in fibroblasts from cystinosis patiens by cysteamine
PII0644 – A proteomic skin disease atlas for accurate and rapid AI-driven clinical decision making
PII0641 – Comparative proteomic analysis of breast cancer and normal tissues with deep plasma profiling using the Mag-Net™ workflow
PII0631 – Optimizing capivasertib response prediction in cancer: unveiling resistance mechanisms through precision proteomics
PII0621 – Harmonization of quantitative proteomics data collected across the international cancer proteogenome consortium
PII0609 – Leveraging LC-MS-based proteomics for improved wheat breeding: unveiling genetic and environmental factors on the expression of flour proteins that influence end-use quality and tolerability
PII0438 – Improved proteome coverage and reproducibility in large cohort analyses using packed emitter columns
PII0435 – Repurposed 3D printer allows economical and programmable fraction collection for proteomics of nanogram scale samples
PII0427 – Evaluation of a transfer-free proteomics approach for the analysis of few dispensed cells: a core facility perspective
PII0421 – Protein aggregation capture assisted profiling of the thiol redox proteome
PII0414 – Automated workflow for deep proteomics profiling of cervical fluid
PII0409 – Magnetic bead-based SPEED enables rapid and high-throughput proteomics sample preparation: a case study in clinical microbiology for species identification and antibiotic resistance detection
PII0406 – Comparative analysis of recombinant trypsin variants for enhanced MS-based peptide identification and quantification
PII0402 – Advancing plasma proteome profiling through cost effective, robust, high-throughput and orthogonal workflows based on hyper-porous magnetic beads
PII0401 – Optimization of sample preparation strategies for high-throughput plasma proteomics
PII0398 – Comparison of plasma and serum abundant protein depletion methods
PII0384 – Overnight enzymatic digestion? Try it at room temperature
PI0367 – Proteomic profiling of preeclampsia
PI0343 – Integrating urine and plasma proteomics to uncover age-specific molecular signatures of pediatric diseases
PI0331 – In-depth analysis of the plasma proteome: Are we enriching extracellular vesicles, platelets, or soluble proteins?
PI0328 – Mag-Net ™ Urine: Improved and complementary workflow for clinical urinary proteomics
PI0327 – Discovery, verification and validation of urinary protein signatures in HIV-associated nephropathy in South Africa
PI0316 – Standardized, fully automated scalable plasma workflows enabled by the Evotip Pure
PI0313 – Proteomic characterisation of clear cell renal cell carcinoma in patients with Von Hippel-Lindau Syndrome
PI0295 – Towards skin cohort proteomics studies: A fine-tuned MS-based workflow applied to Pachyonychia congenita
PI0281 – High-throughput LC-MS for plasma proteomics in patients with stroke
PI0271 – Neuromelanin granules show a characteristic proteomic profile in Parkinson’s disease
PI0259 – Spatial proteomics characterizes the transition of precancerous lesions of the fallopian tube to invasive cancer
PI0186 – Utilising data-independent acquisition mass spectrometry (DIA-MS) to enable rapid profiling of the human secretome
PI0154 – A multi-year longitudinal harmonization of quality controls in mass spectrometry proteomics core facilities
PI0142 – Scalable single cell analysis towards 1000 samples per day using the Evosep whisper zoom methods on the timsTOF Ultra2
PI0107 – SysQuan: a novel strategy for the absolute quantitation of human proteins
PI0106 – Single-cell proteomics and AP-MS to elucidate auditory mechanoelectrical transduction in mammalian cochlea
PI0063 – Universal, unbiased DIA-Based metaproteomics sample processing and database search workflow for comprehensive metaproteomic analysis
PI0025 – Accelerating single-shot phosphoproteomics by identification and quantitation of > 100.000 phosphosites in human cell lines
PI0018 – Deciphering the signaling mechanisms of the C-type lectin receptor Dectin-1 in myeloid cells using high throughput proteomics
OP75 – The HDL proteome represents a novel, sensitive biomarker of metabolic inflammation and metabolic health in obesity that can track both disease progression and regression
OP67 – Achieving quantitative accuracy in large-scale DIA proteomics
OP62 – Spatially resolved multi-omics to decipher molecular pathology for idiopathic pulmonary fibrosis
OP55 – A complete and automated end-to-end sample preparation strategy for high-throughput and standardized proteomics with high sensitivity
OP53 – Combining Proteome Integral Solubility Alteration (PISA) assay and one-tip workflow for a streamlined and high-throughput drug target deconvolution
OP37 – End-to-end transfer learning in DIA proteomics for the characterization of unseen peptide modifications
OP36 – In-depth and high-throughput single-cell proteomics workflow defines function subtypes
OP34 – From discovery to clinic: deep visual proteomics for advances precision medicine
OP27 – Mass spectrometry-based proteomics at extreme scale reveals biomarkers for adverse pregnancy outcomes
OP09 – Deep visual proteomics advances human colon organoid models by revealing a switch to an in vivo-like phenotype upon xenotransplantation
KN17 – Single-cell and spatial proteomics workflows for in-depth tissue mapping
OP06 – Multi-omics biomarker approaches in precision medicine

Monday, October 21, 2024: 08:00 – 09:00 – Conference room 3 & 4

HUPO 2024 breakfast seminar

STANDARDIZING AND SCALING AUTOMATED WORKFLOWS FOR CUTTING EDGE PROTEOMICS

Join us for breakfast and get the newest data of proteomics workflows, scientific discussions, and new discoveries from Evosep.
Learn more about the full programme at HUPO 2024

Monday, October 21, 2024: 08:00 – 09:00 –

Conference room 3 & 4

HUPO 2024 breakfast seminar

Join us for breakfast and get the newest data of proteomics workflows, scientific discussions, and new discoveries from Evosep.
Learn more about the full programme at HUPO 2024

Proteomics in Pathology

Talk by Prof. Dr. Stephan Singer, Institute of Pathology, Universitätsklinikum Tübingen

In “Proteomics in Pathology,” Prof. Dr. Stephan Singer will discuss how proteomics is taking pathological diagnostics to the next level by offering deeper molecular insights into diseases. Focusing on its application in gastrointestinal and hepato-biliary pathology, he will highlight how proteomic data enhances diagnostic precision and informs personalized treatment strategies. This talk will be invaluable for those interested in the cutting-edge integration of proteomics into clinical practice.

Acrivon predictive precision proteomics (AP3)-based drug development

Talk by Valentina Siino, Principal Scientist at Acrivon Therapeutics

WEE1 and PKMYT1 kinases play essential roles in cell cycle checkpoints and DNA damage response. Genetic interaction has been documented between WEE1 and PKMYT1, and clinical trials have reported clinical activity with WEE1 inhibitors adavosertib (adavo), azenosertib (azeno) and the PKMYT1 inhibitor lunresertib (lunres). Here, we report the discovery and characterization of ACR-2316, a dual inhibitor of WEE1 and PKMYT1 specifically designed for optimal selectivity through co-crystallography and superior single agent activity uniquely enabled by Acrivon Predictive Precision Proteomics (AP3).

In conclusion, ACR-2316 is a potentially first-in-class, selective dual WEE1/PKMYT1 inhibitor with superior preclinical single-agent activity compared to clinical benchmark WEE1 or PKMYT1 inhibitors. ACR-2316 is progressing through IND-enabling studies in preparation for clinical monotherapy development.

Monday, October 21, 2024: 19:30 – 23:00 – Lohrmanns Brauerei & Restaurant

Evosep User appreciation Event

Join us Monday, October 21 at our User Meeting at HUPO 2024 and meet company experts as well as fellow Evosep One users for informal networking, buffet with refreshments, and knowledge exchange.

Location of the event will be at Lohrmanns Brauerei & Restaurant, Kraftwerk Mitte 6, 01067 Dresden.

The distance to the event from ICD (International Congress Center Dresden) is 1.1 km, which takes approximately 15 minutes by foot – we recommend using Google Maps for accurate directions.

If arriving by public transport go to Dresden Kongresszentrum / Haus der Presse Station and take Line 6 to Dresden Bahnhof Mitte (one stop). Walk 350 meters to Kraftwerk 6. Transport time is around 15 minutes.

It is possible to arrive by taxi. The fastest way to get a taxi is by the parking entrance of ICD. Transport time is 4-6 minutes. The taxi fare ranges from 5-8 EUR.