Maximize insights, Minimize complexity
Evosep Biolabs makes LC-MS based proteomics
easy to adopt and scale
At Evosep Biolabs we support life science organizations in adopting scalable, LC-MS-based plasma proteomics by simplifying every step of the process. We help you with expert guidance and standardized, automated workflows, fully integrated with the Evosep One LC system, to enable seamless implementation within existing operations.
From biomarker discovery and drug development to precision medicine and contract research, we provide ready-to-deploy workflows that reduce time-to-data, minimize complexity, and deliver high-quality, reproducible results. Partner with us to bring advanced plasma proteomics into your organization with confidence.
What you get
Transitioning to LC-MS-based plasma proteomics is easier than you think. Evosep Biolabs makes it easier to step into the future of plasma proteomics, accelerating your biomarker discovery, drug development, and clinical research with confidence.
Our team supports your success from day one:
Expert consultation
Customized guidance on adopting standardized LC-MS plasma proteomics tailored to your organizational requirements.
Scalable solutions
Proven strategies for automating and scaling workflows to support high-throughput proteomics.
No LC-MS skills needed
Analytical validation
Transforming plasma proteomics with mass spectrometry
Liquid chromatography mass spectrometry (LC-MS) has matured beyond its origins as a specialized research technique. Today, it is a robust, high-throughput platform used in regulated laboratories, clinical trials, and large-scale biomedical studies.
While genomics and transcriptomics offer valuable insights into genetic potential and transcriptional activity, they are limited in elucidating what is happening at the functional level. LC-MS provides a complementary real-time view by directly measuring proteins, the active molecules that drive biological function.
Modern LC-MS enables accurate, reproducible protein measurements directly from patient samples, capturing real-time biological changes as they occur. These data-rich, functional insights are essential for uncovering disease mechanisms, monitoring treatment responses, and advancing precision medicine.
Unlocking actionable insights with LC-MS
Proteins are the active drivers of biology, shaping cellular activities and responding dynamically to health and disease. Understanding their behaviour is key for identifying therapeutic targets and validating clinical biomarkers.
Where NGS predicts potential outcome, LC-MS reveals what is actually happening in the body. This allows you to move beyond genetic snapshots to capture the dynamic, functional layer of biology. Just as RNA-seq quantifies gene expression, LC-MS accurately quantifies the proteins encoded by genes providing a functional readout of biological activity. By measuring proteins directly from blood plasma, LC-MS-based plasma proteomics connects molecular understanding with clinical impact.
Delivering high-resolution, quantitative data that translate complex biology into real-world, actionable insights.
Decoding biology through the plasma proteome
Blood plasma offers a unique window into human biology, providing minimally invasive access to real-time physiological and pathological changes across tissues and organs. As the most used biofluid in clinical diagnostics, plasma holds immense potential for biomarker discovery and translational research.
However, plasma is also one of the most analytically challenging biofluids. A few highly abundant proteins can obscure detection of low-abundance biomarkers critical for disease detection and therapeutic monitoring. Realizing the full promise of plasma proteomics requires analytical workflows that are not only sensitive and robust, but also scalable.
At Evosep Biolabs we provide streamlined solutions that enables generation of high-throughput insights into the plasma proteome with ease.
“At Evosep Biolabs, we’re not just advancing the adoption of LC-MS-based plasma proteomics – we’re simplifying it. Through our advanced workflows and expert team, we empower our partners to fast-track discovery, accelerate research breakthroughs, and uncover new biological insights.”
Michael Lund Nielsen, Head of Biolabs & Scientific Projects at Evosep
Advancing scalable plasma proteomics
Traditional sample preparation and LC-MS workflows often suffer from variability, compromise data integrity, and high per-sample costs. As plasma proteomics scales to larger clinical cohorts and applications, the need for efficient, reproducible, and scalable workflows becomes critical.
Scalability is key to unlocking the full potential of plasma proteomics, enabling analysis across thousands of patient samples to uncover biological signals, map disease mechanisms, and identify new therapeutic targets.
Automation unlocks scalability
Automation alleviates the bottlenecks of manual sample handling, delivering consistent, high-quality results while increasing throughput. At Evosep Biolabs we have redefined scalable plasma proteomics with miniaturized, fully automated workflows designed for large/cohort studies. Our solutions deliver:
- Lower sample processing costs
- Unmatched consistency & robustness
- Confident high-throughput scalability
Reliable and robust end-to-end workflows
Our high-throughput workflows are designed for robustness, reproducibility, and efficiency at scale, enabling deep LC-MS-based plasma analysis from as little as 1uL of sample. This allows for confident, large-scale studies without compromising on depth or quality.
Key features include:
- Comprehensive proteome coverage: Identify up to 5,000 proteins per sample, unlocking novel biomarkers and therapeutic targets
- Exceptional reproducibility: Achieve <15% median Inter-assay CV, ensuring precise and reliable assay readouts
- High-throughput capability: Process >1,000 patient samples per workflow iteration accelerating large-scale studies
- Standardized scalability: Ensure reliable, high-quality data generation for large patient cohorts and multi-site studies
How we help
1. Workflow implementation & expert consultation
- We provide end-to-end solutions and support for adopting high-throughput, automated LC-MS-based plasma proteomics – ensuring seamless transition into routine operations.
2. Proof-of-concept analysis
- De-risk internal adoption with access to Evosep Biolabs’ expertize for workflow validation prior to full-scale implementation.
- We offer flexible collaboration models to suit your needs – whether you prefer to insource or outsource analytical capacity.
All workflows are designed for use with the Evosep One LC system. To enable full workflow integration, partners should have access to a mass spectrometer and compatible liquid handling robot.
Get in touch
Evosep Biolabs makes adopting scalable plasma proteomics simple. With cutting-edge solutions and expert guidance, you can confidently invest in the right strategy for your research.
Get in touch with our team today for a consultation on how scalable plasma proteomics can advance your research
