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The social architecture of an in-depth cellular protein interactome

by Eva Bryderup

This publication by the Mann group describes a comprehensive and scalable strategy to define the network architecture of the cellular interactome. They applied this to more than 4000 pull-downs not generate a highly structured network of 3,909 proteins connected by...

Data independent acquisition enables deep and fast label-free dynamic organellar mapping

by Eva Bryderup

This publication by the Borner group, describes a DIA workflow to establish organellar maps, which combines cell fractionation and shotgun proteomics into a profiling analysis of subcellular localization. They apply this to HeLa cells and investigate changes in...

Evaluation of Disposable Trap Column nanoLC–FAIMS–MS/MS for the Proteomic Analysis of FFPE Tissue

by Eva Bryderup

This publication by the Kuster group presents a robust workflow to support the analysis of large cohorts of patient samples using formalin-fixed paraffin-embedded FFPE tissue. They make use of online fractionation by FAIMS requiring 50% less sample than conventional...

AlphaTims: Indexing trapped ion mobility spectrometry – time of flight data for fast and easy accession and visualization

by Eva Bryderup

This publication by the Mann group, introduces the open-source AlphaTims package with a stand-alone graphical user interface or as part of their AlphaPept ecosystem. With this package, unprocessed data are indexed, accessed, and visualized by a combination of...

A universal peptide matrix interactomics approach to disclose motif dependent protein binding

by Eva Bryderup

This publication by the Mertins group describes an optimized method to study protein-protein interactions mediated by intrinsically disordered regions. They demonstrate the feasibility of an optimized method for a PRotein Interaction Screen on a peptide MAtrix...
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  • ASMS2022
  • Events
    • Conferences
    • EuPa 2022
    • webinars
  • Shop
  • products
    • Evosep One
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    • Columns and emitters
  • Methods
    • Standard methods
      • 300 SPD
      • 200 SPD
      • 100 SPD
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    • EVOSEP+
      • Extended method
      • High organic method
      • Whisper 40SPD
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  • Applications
    • Automation
    • Clinical research
    • COVID-19
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