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AlphaTims: Indexing trapped ion mobility spectrometry – time of flight data for fast and easy accession and visualization

by Eva Bryderup

This publication by the Mann group, introduces the open-source AlphaTims package with a stand-alone graphical user interface or as part of their AlphaPept ecosystem. With this package, unprocessed data are indexed, accessed, and visualized by a combination of...

A universal peptide matrix interactomics approach to disclose motif dependent protein binding

by Eva Bryderup

This publication by the Mertins group describes an optimized method to study protein-protein interactions mediated by intrinsically disordered regions. They demonstrate the feasibility of an optimized method for a PRotein Interaction Screen on a peptide MAtrix...

A personalized mass spectrometry-based assay to monitor M-protein in multiple myeloma patients (EasyM)

by Eva Bryderup

This publication by the Trudel group describes the development of a non-invasive MS-based assay, called EasyM, which is used to assess minimal residual disease, a measure of depth of response to treatment, which has become an important parameter in assessing the...

Synthetic Antigen Presenting cells reveal the diversity and functional specialisation of extracellular vesicles composing the fourth signal of T cell immunological synapses

by Eva Bryderup

In this publication, the Dustin group investigates the synaptic particle biogenesis and composition in different T-cell subsets. They use proteomics to reveal the diversity and functional specialization of extracellular vesicles composing the fourth signal of T cell...

Proteomics of resistance to Notch1 inhibition in acute lymphoblastic leukemia reveals targetable kinase signatures

by Eva Bryderup

In this publication, the Olsen group highlights the potential of proteomics to dissect alterations in cellular signaling and identify druggable pathways in cancer. They identify protein kinase C delta (PKCδ) inhibition as a strategy to overcome resistance to Notch1...
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