| Single cell proteomics by mass spectrometry reveals deep epigenetic insight into the actions of an orphan histone deacetylase inhibitor | | Publication | 2024 | | | 100 SPD, 200 SPD, 30 SPD, 500 SPD, 60 SPD | Bruker timsTOF SCP | Read publication here
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| Standardized, fully automated neat plasma and Mag-Net enrichment workflows enabled by the Evotip Pure | | Poster | 2024 | | | 200 SPD, 500 SPD | Bruker timsTOF HT | Read poster here
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| Scalability for high-throughput proteomics – Evotip Pure integration with the Biomek i5 liquid handler | | Application note | 2024 | | | 200 SPD, 500 SPD | Bruker timsTOF HT | Read application note here
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| Cost-efficient and scalable end-to-end workflow on the Opentrons OT-2 for neat plasma utilizing Evotip Pure | | Application note | 2024 | | | 100 SPD, 200 SPD | Bruker timsTOF HT | Read application note here
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| Scalability for high-throughput proteomics – Evotip Pure integration with the Biomek i5 liquid handler | Automation, Plasma | Application note | 2024 | With the development of faster and more sensitive mass spectrometers, proteomics has become an essential tool across diverse applications in both academia and industry. As proteomics studies become larger and analyses become more routine, the demand for standardized and scalable solutions is increas- ing. To address this need, we present four fully automated workflows developed … | | 200 SPD, 500 SPD | Bruker timsTOF HT | Download application note here
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| Cost-efficient and scalable end-to-end workflow on the Opentrons OT-2 for neat plasma utilizing Evotip Pure | Automation, Plasma | Application note | 2024 | Plasma proteomics stands at the forefront of biomedical research as it offers invaluable insights into disease progression and holds immense potential for minimally invasive diagnostics. With recent advancements toward faster LC-MS analysis, the demand for robust, high-throughput, and cost-efficient sample preparation has increased. To address this, we present a fully automated plasma sample preparation workflow … | | 100 SPD, 200 SPD | Bruker timsTOF HT, SCIEX ZenoTOF 7600 | Download application note here
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| AlphaPept: a modern and open framework for MS-based proteomic | | Publication | 2024 | | | 200 SPD | timsTOF Pro | Read publication here
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| Automated high-throughput biological sex identification from archaeological human dental enamel using targeted proteomics | | Publication | 2024 | | | 200 SPD, 30 SPD | Thermo Orbitrap Exploris 480 | Read publication here
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| Homo sapiens reached the higher latitudes of Europe by 45,000 years ago | | Publication | 2024 | | | 200 SPD | Thermo Orbitrap Exploris 480 | Read publication here
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| Full Mass Range ΦSDM Orbitrap Mass Spectrometry for DIA Proteome Analysis | | Publication | 2024 | | | 100 SPD, 200 SPD, 60 SPD | Thermo Orbitrap Exploris 480 | Read publication here
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| Single cell proteomics by mass spectrometry reveals deep epigenetic insight and new targets of a class specific histone deacetylase inhibitor | | Publication | 2024 | | | 100 SPD, 200 SPD, 30 SPD, 300 SPD, 500 SPD, 60 SPD | Bruker timsTOF SCP | Read publication here
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| Exploring the benefits of differential mobility separation and SWATH data independent acquisition for complex proteomic sample analysis | DIA | Poster | 2023 | | | 100 SPD, 200 SPD | SCIEX TripleTOF 6600 MS system | Read publication here
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| Rapid and robust PTM peptide mapping for biologics with the Evosep One and the ZenoTOF 7600 | | Poster | 2023 | | | 100 SPD, 200 SPD, 300 SPD, 60 SPD | SCIEX ZenoTOF 7600 | Read app note here
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| Vacuum Insulated Probe Heated Electrospray Ionization Source Enhances Microflow Rate Chromatography Signals in the Bruker timsTOF Mass Spectrometer | | Publication | 2023 | | | 100 SPD, 15 SPD, 200 SPD, 30 SPD, 60 SPD | Bruker timsTOF | Read publication here
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| Towards a Standardized Omics Platform with the 200 samples per day method | Technology | Application note | 2023 | This application note describes the 200 samples per day standard method. Get an overview of the method, the chromatographic performance and the results expected from Hela standard injections. | | 200 SPD | Thermo Orbitrap Exploris 480 | Download application note
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| Evosep One solves the proteomics dilemma – covering high throughput analysis and proteome depth | Fractionation, Technology | Application note | 2023 | The Evosep One offers a diverse range of applications, utilizing its six standard methods. It caters to various use cases, spanning from comprehensive proteome analysis with fractionation strategies to ultra high-throughput single-shot analysis. | | 100 SPD, 200 SPD, 30 SPD, 300 SPD, 60 SPD | | Download application note
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| Flexibility, speed, and throughput for high proteome coverage using Zeno SWATH data-independent acquisition (DIA) coupled with the Evosep One system | | Application note | 2023 | | | 100 SPD, 200 SPD, 30 SPD, 300 SPD, 500 SPD, 60 SPD | SCIEX ZenoTOF 7600, timsTOF Pro 2 | Read publication here
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| Vacuum Insulated Probe Heated ElectroSpray Ionization source (VIP-HESI) enhances micro flow rate chromatography signals in the Bruker timsTOF mass spectrometer | | Publication | 2023 | | | 100 SPD, 200 SPD, 30 SPD, 60 SPD, Extended method | Bruker timsTOF Pro | Read publication here
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| Chromatographic separation of peptides and proteins for characterization of proteomes | | Journal article | 2022 | | | 100 SPD, 200 SPD, 60 SPD | Thermo Orbitrap Exploris 480 | Read publication here
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| Slice-PASEF: fragmenting all ions for maximum sensitivity in proteomics | | Publication | 2022 | | | 200 SPD | Bruker timsTOF Pro | Read publication here
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| High-throughput quantitative proteomics using Zeno SWATH data-independent analysis (DIA) and the Evosep One system | | Application note | 2022 | | | 100 SPD, 200 SPD, 30 SPD, 60 SPD | SCIEX ZenoTOF 7600 | Read publication here
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| A fast and sensitive absolute quantification assay for the detection of sars-cov-2 peptides using parallel reaction monitoring mass spectrometry | | Publication | 2022 | | | 200 SPD | Thermo Q Exactive HF | Read publication here
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| Fully Automated High-Throughput Host Cell Protein Analysis of Highly Diverse Samples | DDA, HCP | Application note | 2021 | Novozymes produces recombinant enzymes and microbial solutions for a plethora of bio-based industries. To meet regulatory demands, they have developed a highly efficient and streamlined HCP workflow, which translate raw samples to data in less than 24 hours, with less than 2 hours of hands-on time. Read more about their workflow in this application note. | | 200 SPD | Bruker timsTOF | Read application note here
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| AlphaTims: Indexing Trapped Ion Mobility Spectrometry–TOF Data for Fast and Easy Accession and Visualization | DDA, DIA, Technology | Publication | 2021 | This publication by the Mann group, introduces the open-source AlphaTims package with a stand-alone graphical user interface or as part of their AlphaPept ecosystem. With this package, unprocessed data are indexed, accessed, and visualized by a combination of tools. | | 200 SPD, 60 SPD | Bruker timsTOF Pro | Read publication here
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| AlphaPept, a modern and open framework for MS-based proteomics | DDA, Technology | Publication | 2021 | This publication by the Mann group, introduces AlphaPept, a Python-based open-source framework for efficient processing of large high resolution MS data sets. They used the 200 samples per day method on the Evosep One to generate test data for computational functionality. | | 200 SPD | Bruker timsTOF Pro | Read publication here
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| Unleashing the power of DIA combined with short gradients using Evosep One | DIA, Technology | Webinar | 2021 | This webinar is part of our Evosep webinar series and hosted by Nicolai Bache, Evosep. Florian Meier and Vadim Demichev discuss their use of the Evosep One, using novel DIA methodologies. | | 100 SPD, 200 SPD, 60 SPD | Bruker timsTOF Pro | Watch webinar
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| High sensitivity dia-PASEF proteomics with DIA-NN and FragPipe | diaPASEF, Technology development | Publication | 2021 | The Ralser and Nesvizhskii groups introduce the latest addition to the DIA-NN software with a neural network-based ion mobility module. DIA-NN was originally conceived to maximize the performance of fast proteomics experiments and here they demonstrate the identification of more than 5000 proteins from the 200 SPD method. | | 100 SPD, 200 SPD, 60 SPD | Bruker timsTOF Pro | Download publication or learn more on our website
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| Rapid, robust and reproducible host-cell protein analysis with Evosep One | DDA, HCP | Webinar | 2021 | This webinar is part of our Evosep webinar series and hosted by Nicolai Bache, Evosep. Jiao Ma and Anders Giessing discuss their use of the Evosep One to perform rapid, robust and reproducible HCP analysis. | | 200 SPD, 60 SPD | Bruker timsTOF Pro, Thermo Orbitrap Fusion Lumos | Watch webinar
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| SPIN – Species by Proteome Investigation | Ancient proteomics, DIA | Publication | 2021 | This publication from the Olsen Group, introduces “Species by Proteome INvestigation” (SPIN), a proteomics workflow capable of querying over 150 mammalian species 200 times a day with the Evosep One. Genetic species determination is an indispensable tool in forensics, archaeology, ecology, and food authentication. | | 100 SPD, 200 SPD, 60 SPD | Thermo Orbitrap Exploris 480 | Download publication
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| diaPASEF: parallel accumulation–serial fragmentation combined with data-independent acquisition | diaPASEF, Technology | Publication | 2020 | A collaboration led by the Mann group at the Max Planck Institute for Biochemistry, Münich describes the development of the latest addition to the PASEF technology. The diaPASEF workflow combines the advantages of DIA such as high degree of reproducibility and data completeness with the effective PASEF technology. | | 100 SPD, 200 SPD, 60 SPD | Bruker timsTOF Pro | Download publication or learn more on our website
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| High throughput proteome and phosphorpoteome sample processing coupled to fast gradient DIA | DDA, DIA, FAIMS, Phosphorylation, PTM, Technology, Tissue, TMT | Publication | 2020 | High throughput workflows for proteomics | | 100 SPD, 200 SPD, 60 SPD | Thermo Orbitrap Exploris 480 | Download publication
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| New Orbitrap Exploris 480 Mass Spectrometer Coupled with Evosep One | DDA, DIA, FAIMS, Technology | Brochure | 2020 | Brochure of Exploris 480 with Evosep data from piece no 1 | | 100 SPD, 200 SPD, 60 SPD | Thermo Orbitrap Exploris 480 | Download brochure
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| Online parallel accumulation – serial fragmentation (PASEF) with a novel trapped ion mobility mass spectrometer | DDA, Technology | Publication | 2018 | Description of timsTOF | | 200 SPD | Bruker timsTOF Pro | Download publication
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| Improving proteome coverage and peptide identification rates in short LC gradients | DDA, DIA, FAIMS, Phosphorylation, PTM, Technology | Video | 2020 | | | 100 SPD, 200 SPD, 60 SPD | Thermo Orbitrap Exploris 480 | Watch
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| High-throughput proteomics with Evosep One | DDA, DIA, FAIMS, Phosphoproteomics, PTM, Technology | Video | 2020 | | | 100 SPD, 200 SPD, 60 SPD | Thermo Orbitrap Exploris 480 | Watch
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| Using Artificial Intelligence on Ultrafast LC-MSMS-DIA runs for Bacterial Identification in Urine | Bacteria, Clinical research, DIA | Video | 2019 | View the recording of our HUPO 2019 lunch seminar, where Florence Roux-Dalvai from Québec Research Center, Canada presents a new strategy for bacterial species identification in urinary tract infection using artificial intelligence on ultrafast LCMS DIA runs. | | 100 SPD, 200 SPD, 60 SPD | Thermo Orbitrap Exploris 480 | Watch
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| High-throughput 4D-Proteomics – Application of dia-PASEF® and the Evosep One for short gradients | DIA, Technology | Application note | 2020 | diaPASEF app note | | 100 SPD, 200 SPD, 300 SPD, 60 SPD | Bruker timsTOF Pro | Download application note
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| timsTOF Pro with PASEF and Evosep One: Maximizing throughput, robustness and analytical depth for shotgun proteomics | DDA, Technology | Application note | 2018 | Read this application note to learn more about the timsTOF Pro with PASEF and the Evosep One for maximizing throughput, robustness and analytical depth for shotgun proteomics. Increased peak capacity via trapped ion mobility spectrometry allows the analysis of 200 samples/day, at formidable analytical depth, with unparalleled robustness. | | 100 SPD, 200 SPD, 60 SPD | Bruker timsTOF Pro | Download publication or download poster
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| Development of mass spectrometry-based targeted assay for direct detection of novel SARS-CoV-2 coronavirus from clinical specimens | Clinical research, Covid-19, DDA, Targeted workflow | Publication | 2020 | This publication by the Akhilesh Pandey group describes a targeted FAIMS-PRM assay on an Orbitrap Exploris 480 MS. More than 700 nasopharyngeal swab samples were analyzed with high specificity and comparable sensitivity to the gold standard RT-PCR method for the diagnosis of SARS-CoV-2. | | 100 SPD, 200 SPD | Thermo Orbitrap Exploris 480 | Download publication
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| A Compact Quadrupole-Orbitrap Mass Spectrometer With Faims Interface Improves Proteome Coverage In Short Lc Gradients | Automation, DDA, DIA, FAIMS, Fractionation, Phosphoproteomics, PTM, Technology, Tissue, TMT | Publication | 2020 | Test of Orbitrap Exploris with DIA and TMT, proteome and phospho. | | 100 SPD, 200 SPD, 60 SPD | Thermo Orbitrap Exploris 480 | Download
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| High-Throughput Proteomics Quantification Enabled by Fast LC Separation and Advanced PRM Acquisition | Phosphorylation, PTM, Targeted workflow | Poster | 2018 | High throughput LC-PRM to monitor the main protein components of AKT/mTOR signaling pathway. | | 100 SPD, 200 SPD, 60 SPD | Thermo Q Exactive HF-X | Download
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