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Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms

by Eva Bryderup

This publication from University of Dundee led by Dario R Alessi, describes how LRRK1, a less studied homologue of LRRK2 regulates growth factor receptor trafficking and osteoclast biology reinforcing that the LRRK enzymes have evolved as major regulators of Rab...

Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites

by Eva Bryderup

This publication from University of Dundee led by Dario R Alessi, describes the validation and development of a new, multiplexed targeted assay that enables the relative quantification of the key components of the LRRK2 pathway, defining the impact of LRRK2 inhibitors...

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    Webinar: Whisper is coming

    Whisper is Here

    15/12/2020j/n/Y4:00pm CET2020-12-15T15:00:00Zg:ia T1 hour
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    In this webinar, we will introduce our next addition to our dynamic environment of specialized applications, EVOSEP+. We are developing a set of nanoflow methods for standard Evosep One hardware, which builds on a robust platform allowing for several thousand uninterrupted injections at very low flow rates. We will demonstrate the expected increase in sensitivity and benchmark the performance directly against our established standard methods.

     

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