A recent study from the Olsen group at University of Copenhagen, has capitalized on the recent developments in both high sensitivity instrumentation and sample preparation methods to perform single-cell pSILAC experiments providing functional information on protein turnover at the single-cell level.

Proteins are the most dynamic molecules in the body, directly influencing cellular health and function. They are also the primary targets for most therapeutic treatments. Through proteomics, we can gain valuable insights into drug efficacy and safety by monitoring proteins in real-time. Significant progress has been made in this field over the past few decades, with recent technological advancements – particularly in the last five years – dramatically increasing both the speed and robustness of proteomics.